Someone can reach Kalampaka with many ways:

From Athens
By road through Athens – Lamia – Domokos – Karditsa – Trikala- Kalampaka.
Distance: 352 km
By train through Athens –Lamia – Paleofarsalos – Karditsa – Trikala – Kalampaka. 

From Thessaliniki
By road through the high way from Thessaloniki – Katerini – Larisa – Trikala – Kalampaka.
Distance: 237 km
By train through Thessaloniki – Larisa – Paleofarsalos – Karditsa – Trikala – Kalampaka.

From Italy and Igoumenitsa:
By road through Igoumenitsa – Ioannina –Metsovo – Kalampaka.
Distance: 246 km

From Mecedonia:
By road through Kozani – Grevena – Kalampaka

Train Routes  and Timetables Hellenic Railways Organisation (O.S.E)
tel. 003024320 22451 
 
 
From Kalampaka to Athens:

06:33 a.m Departs from: Kalampaka  Arrival Time:11.15 am (Intercity)
17.36 p.m Departs from: Kalampaka  Arrival Time:22.08 pm (Intercity)

08:53 a.m Departs from: Kalampaka Conection from Paleofarsalos Arrival Time Athens 14.10 pm
13.31 p.m Departs from: Kalampaka Conection from Paleofarsalos Arrival Time Athens 18.18 pm
15.32 p.m Departs from: Kalampaka Conection from Paleofarsalos Arrival Time Athens 19.49 pm

From Athens to Kalampaka

8.21 a.m Departs from: Athens  Kalambaka Arrival Time:13.00 pm (Intercity)
15.53 p.m Departs from: Athens  Kalambaka Arrival Time:20.10 pm (Intercity)

06.50 a.m Departs from: Athens Conection from Paleofarsalos  Arrival Time Kalambaka 11.10 am
09.21 a.m Departs from: Athens Conection from Paleofarsalos  Arrival Time Kalambaka 14.38 pm
10.51 a.m Departs from: Athens Conection from Paleofarsalos  Arrival Time Kalambaka 15.31 pm
13.21 p.m Departs from: Athens Conection from Paleofarsalos  Arrival Time Kalambaka 17.35 pm